With this major update to our mousepost tool, mousepost V2.0, we aim to provide an overview of the non-synonymous mutations, both SNP and small insertions/deletions, that affect the protein coding transcripts of 52 (from 36) often used laboratory strains of mice. We identified mutations on a per codon basis and classified them in 4 main groups: Stop Gained (SG), for mutations leading to an early stop codon, Stop Loss (SL) for mutations removing a stop codon, Start Codon (SC) for mutation affecting the start codon and Mutated (MUT), for all others. Mutations not affecting a stop codon were analyzed with PROVEAN in order to predict the effect on the final protein function.
When using data retrieved from this website, please refer to one of the following papers: Complete overview of protein-inactivating sequence variations in 36 sequenced mouse inbred strains or Overview of inactivating mutations in the protein-coding genome of the mouse reference strain C57BL/6J
Website developed by the Claude Libert group (VIB-UGent).
This table provides an overview of the data and shows the number of genes and transcripts present in each of the three classes per strain
Obtain information of proteins different from the C57BL/6J reference strain
Obtain lists of all transcripts in the three classes (Stop Gain, Stop Loss and Mutated) in any of the 36 strains.
Search for deviation from the reference sequence in any number of strains for: (i) one or more genes of interest, (ii) all genes in a genomic region, (iii) all genes annotated with a specific function.
Information on proteins that are different in C57BL/6J (reference) compared to other strains
Pairwise comparisons between included strains